AC BioScience is focused on personalized molecular therapies; that is, medical care designed to optimize efficiency or therapeutic benefit for particular groups of patients by using molecular profiling.
We bring to clinical validation unique scientific discoveries identified by our co-founder to dramatically impact the efficacy of cancer treatment therapies. Clinical trials are scheduled to start for two of its proprietary molecules in 2022.
The company develops novel uses for existing molecules with well-established safety and tolerance profiles. Our compound for tumor vascular normalization has a history of FDA-approved Phase 1 data in a different application
To maximize resources and ensure sustainability, the company operates with a lean organization. This is possible through the deep involvement of the two co-founders in strategic and scientific development and operations, and the obtainment of research grants. Drug development and clinical validation are outsourced to specialist companies or academic institutions.
For one of its molecules, the company is challenging the traditional antiangiogenic approach to cancer therapy. Our neo-adjuvant therapy is designed to improve the efficacy of all types of chemo- and radiotherapy for solid tumors.
One of our new molecules (ACB1801) also holds promise, within immune-oncology, to induce F-actin network remodeling and thereby potentiate the therapeutic benefit of anti-PD-1.
The company’s initial targets are the treatment of tumoral and immunological pathologies.
One of our projects aims to improve the efficacy of chemo- and radiotherapy in the treatment of solid tumors, using sphingosine-1-phosphate (S1P) metabolism modulators as tumor vascular normalizers.
A Beta-carboline derivative (ACB1801) has successfully undergone pre-clinical testing, the goal of which was to revert the tumor phenotype and thereby enhance the efficacy of checkpoint-inhibitor immune therapy.
The company has also acquired a patent for an antitumor cationic amphipathic peptide (CAP6). It belongs to a new generation of cancer drugs with limited side effects and generally greater efficacy.
Our “success by design” business model starts with the identification of new medical strategies for the treatment of cancer.
AC BioScience’s objective is to turn innovation into economic value and to secure optimum protection for its intellectual property. To this end, the company has been diligently protecting its innovations, research and validation work by filing patent applications or acquiring patents for their broadest applications.
A Swiss government-funded collaborative pre-clinical research project with the Molecular Pharmacology Group of the University of Geneva has started in April 2018. It aims at reinforcing the proof-of-concept supporting the use of Sphingosine-1-phosphate metabolism modulators as tumor vascular normalizers.
A pre-clinical murine study is being conducted at the biomedical research laboratories of the LIH to measure the impact of tumor reversion on anti-PD-1 efficacy.
An Innosuisse-funded collaborative research project with the Biochemistry Group of the University of Lausanne will start in June 2020. The goal of the project is to demonstrate that the administration of immuno-modulating compounds can be used to overcome parasite-elicited immune subversion to treat certain infectious diseases.
In-vivo studies are being conducted at the Institut Gustave Roussy in Paris to establish a biological PoC neo-adjuvant to radiotherapy for a combination treatment of S1P metabolism modulators and radiotherapy to improve the treatment of HNSCC, and radiation therapy in combination with ACB1801 and anti PD-1 treatment.
Professor Christian Auclair maintains a network of partnerships with the leading centers in the fight against cancer in Europe. Research and clinical work is being performed with the Institut Curie in Paris, the University of British Columbia in Vancouver and EPFL in Lausanne.